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Liksom alla läkemedel kan detta läkemedel orsaka biverkningar, men alla användare behöver inte få dem. Flera av biverkningarna är dosberoende och som för alla opioider finns det hazard fileör beroende med Petidin Meda. Vid upprepad dosering till den ammande kvinnan kan petidin och metaboliten (norpetidin) medföra CNS-påverkan hos barnet.

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